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About Xeomin®

What is Botulinum Toxin treatment?

Botulinum Toxin, which acts on nerve endings in muscles to prevent muscle contractions. By reducing these contractions, Botulinum Toxin can temporarily reduce wrinkles and prevent wrinkle formation.

How Xeomin® work?

XEOMIN® (incobotulinumtoxinA) is a new generation, pure botulinum toxin, free from impurities*including complexing proteins, which prevent muscle contractions. By reducing these contractions, XEOMIN® can temporarily reduce the wrinkles between eyebrows e.g. glabellar frown lines2. XEOMIN® acts in 2-3 days3,results last up to 4 months4.

* Impurities refer to the presence of complexing proteins, inactive neurotoxin, flagellin and bacterial DNA contaminants. 1

Reference:

1. Park JY, et al. Neurotoxin impurities: A Review of threats to Efficacy. Plast Recontr Surg Glob Open. 2020;8(1):e2627

2. XEOMIN® (incobotulinumtoxinA) Product Information.

3. Prager W et al. Clin Intery Aging.2013; 8 : 449-456

4. Rappl T, et al. Onset and Duration of Effect of IncobotulinumtoxinA, OnabotulinumtoxinA, and AbobotulinumtoxinA in the Treatment of Glabellar Frown Lines: A Randomized, Double-Blind Study. Clin Cosmet Investig Dermatol. 2013 Sep 24; 6:211-19.

IS YOUR BOTULINUM TOXIN TREATMENT LOSING ITS EFFECT?^

Definition: the ability of the body to neutralise the Botulinum Toxin product, which consequently results in little to no visible effect after multiple rounds of treatments.

This is caused by the development of neutralising antibodies against the active neurotoxin. The risk of developing resistance may be increased by the presence of impurities*.

^ This refers to (1) experiencing shorter durations of efficacy as compared to previous treatments, (2) treatment not producing the same desired outcome and / or (3) treatment becomes totally ineffective.

WHAT ARE IMPURITIES*? AND HOW THEY CAN AFFECT YOU?

1 WHATare impurities* in Botulinum Toxins?

Varying degrees of impurities* are found in most Botulinum Toxin A formulations due to differences in manufacturing and purification processes. These impurities* consist of complexing proteins, inactive neurotoxin, flagellin and bacterial DNA.

2 WHYare they harmful?

Impurities* in Botulinum Toxins increase the risk of activating the immune system, leading to the formation of neutralising antibodies (NABs) that diminish treatment efficacy over time or even cause complete non-response.

3HOWcan I prevent this?

It is important to choose a Pure Toxin with Zero Impurities* right from the start to ensure optimal results with every Botulinum Toxin treatment.

What is complexing proteins?

Complexing proteins are foreign bacterial proteins found within most Botulinum Toxins, initially thought to stabilise the active neurotoxin and facilitate the uptake of Botulinum Toxins into target tissue. However, Complexing proteins do not play an active role in treatment efficacy. German Immunologist Professor Michael Martin explained that we do not need foreign complexing proteins, if we inject botulinum Toxins with complexing proteins, the presence of complexing proteins may result in immune response and lead to the formation of neutralizing antibodies.

What is Botulinum Toxin Resistance?

Repeat treatments of Botulinum Toxin with impurities* is possible to develop resistance, this is caused by the development of neutralising antibodies against the active neurotoxin, which consequently results in little to no visible effect after multiple rounds of treatments. Choose US FDA approved Botulinum Toxin with zero impurities* which reduces the risk of neurtralising antibody formation.

* Impurities refer to the presence of complexing proteins, inactive neurotoxin, flagellin and bacterial DNA contaminants. 1

Reference: 1.Park JY, et al. Neurotoxin impurities: A Review of threats to Efficacy. Plast Recontr Surg Glob Open. 2020;8(1):e2627

XEOMIN®- THE NEW GENERATION PURE TOXIN

ZERO IMPURITIES* = LOWER RISK OF NEUTRALISING ANTIBODY FORMATION

* Impurities refer to the presence of complexing proteins, inactive neurotoxin, flagellin and bacterial DNA contaminants. 1

1. Park JY, et al. Neurotoxin impurities: A Review of threats to Efficacy. Plast Recontr Surg Glob Open. 2020;8(1):e2627

 

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